Grease a baking dish with cooking spray or olive oil Recipe

If you’re looking for a warm, satisfying dish packed with protein and vibrant greens, this High-Protein Spinach and Artichoke Chicken Casserole is an absolute winner. The blend of tender shredded chicken, fresh spinach, and tangy artichokes combines perfectly with creamy Greek yogurt and melty cheeses to create a dish that is comfort food with a nutritious twist. One of the key secrets to this recipe is to grease a baking dish with cooking spray or olive oil before adding the casserole mixture, ensuring even cooking and that wonderful golden crust we all love. Whether it’s for a family dinner or meal prep, this casserole delivers hearty flavor every time with that perfect balance of creamy and crunchy textures.

Ingredients You’ll Need

Keeping the ingredients simple yet impactful is what makes this casserole so special. Each component enhances the dish by adding layers of flavor, texture, and nutrition—trust me, you’ll appreciate every bite.

• 2 cups cooked, shredded chicken: Rotisserie chicken makes this easy and flavorful.
• 1 cup chopped fresh spinach: Adds vibrant color and a fresh, leafy texture, but frozen works well too.
• 1 cup canned artichoke hearts, drained and chopped: Brings a tender, tangy bite that balances richness.
• 1 cup Greek yogurt: Creamy and packed with protein, a healthier alternative to sour cream.
• 1 cup shredded mozzarella cheese: For that melty, gooey goodness everyone loves.
• ½ cup grated Parmesan cheese: Adds a touch of sharpness and depth to the flavor profile.
• 3 cloves garlic, minced: Infuses the dish with a fragrant aroma and subtle heat.
• 1 tablespoon olive oil: Used for sautéing and greasing the baking dish—key for amazing texture.
• 1 teaspoon dried oregano: Provides a warm, herby note that ties the ingredients together.
• 1 teaspoon onion powder: Enhances savory depth without overpowering.
• 1 teaspoon salt: Balances all the flavors perfectly.
• ½ teaspoon black pepper: Adds a gentle kick for complexity.
• 1 cup breadcrumbs (optional): For a crunchy, golden topping that adds irresistible texture.

How to Make Grease a baking dish with cooking spray or olive oil

Step 1: Preheat the Oven

Get your oven warmed up to 350°F (175°C) so it’s ready to turn your casserole into a bubbling, golden masterpiece. Preheating ensures even cooking and that perfect crust.

Step 2: Sauté Spinach and Garlic

In a skillet, heat 1 tablespoon of olive oil over medium heat and add the minced garlic. The aroma of garlic sizzling in olive oil is downright irresistible. Then toss in your fresh spinach and cook just until it’s wilted and still vibrant green. This step softens the spinach and intensifies its flavor.

Step 3: Mix All Ingredients

In a large bowl, combine the shredded chicken, sautéed spinach and garlic, chopped artichoke hearts, Greek yogurt, mozzarella, Parmesan, oregano, onion powder, salt, and black pepper. Stir everything together until it’s evenly mixed—this ensures every spoonful is bursting with flavor.

Step 4: Grease a baking dish with cooking spray or olive oil and Transfer Casserole

This is the moment where the recipe really shines. Grease a baking dish with cooking spray or olive oil to keep the casserole from sticking and to help create a golden crust on the edges. Pour in the mixture evenly and smooth the top.

Step 5: Add Breadcrumb Topping

If you love a bit of crunchy texture, sprinkle your breadcrumbs evenly over the top. These will toast beautifully in the oven, adding a satisfying contrast to the creamy filling underneath.

Step 6: Bake to Perfection

Place your casserole in the oven and bake for 30 to 35 minutes. You’ll want to look for a bubbling edge and a golden, lightly browned top—that’s the sign that your dish is ready to be enjoyed.

Step 7: Cool Slightly Before Serving

Let your casserole rest for a few minutes outside the oven. Cooling allows everything to set, making it easier to slice and serve, and perfectly preventing any cheese from pulling away or dripping.

How to Serve Grease a baking dish with cooking spray or olive oil

Garnishes

Fresh herbs like chopped parsley or basil can add a burst of color and freshness just before serving. A light drizzle of extra virgin olive oil on top enhances the richness while adding a subtle fruity aroma. Garnishes can elevate the dish from hearty to beautiful in seconds.

Side Dishes

Pair this casserole with a light side salad of mixed greens tossed in lemon vinaigrette for a refreshing contrast. Roasted vegetables or a simple cucumber and tomato salad can also balance the richness and add texture to your meal.

Creative Ways to Present

You can serve this casserole straight from the baking dish family-style to create a cozy atmosphere or portion it out into individual ramekins for a more elegant presentation. Using colorful serving dishes makes the meal feel even more inviting and festive.

Make Ahead and Storage

Storing Leftovers

Once cooled completely, store leftovers in an airtight container in the refrigerator. This casserole holds up well for up to 3 to 4 days, making it perfect for quick lunches or dinners afterward.

Freezing

If you want to batch cook, you can freeze the prepared casserole before baking or after it’s fully cooked and cooled. Wrap it tightly in foil and plastic wrap or use a freezer-safe container. It will stay good for up to 2 months in the freezer.

Reheating

Thaw frozen portions in the refrigerator overnight for best results. Reheat in the oven at 350°F until warm throughout and the edges start to crisp again, about 20-25 minutes. You can also microwave single servings, but the oven will give you a nicer texture.

FAQs

Can I substitute Greek yogurt with sour cream?

Absolutely! Sour cream will work fine and gives a slightly richer, tangier flavor. Greek yogurt keeps things a bit lighter and adds protein, but it’s a personal preference.

What can I use instead of breadcrumbs for the topping?

If you want a crunchy topping without breadcrumbs, crushed nuts like almonds or walnuts can be a delicious alternative. You can also omit the topping entirely for a creamier finish.

Is this casserole gluten-free?

The casserole itself is naturally gluten-free if you skip the breadcrumbs or use gluten-free breadcrumbs. Always double-check labels on seasonings to be safe.

Can I prepare this dish vegetarian?

Sure thing! Just replace the shredded chicken with cooked chickpeas or a plant-based chicken alternative. It will still be delicious and packed with protein.

How do I know when the casserole is fully cooked?

Look for bubbling edges and a golden brown top, especially if you added the breadcrumb topping. The cheese should be melted and the casserole heated through, about 30 to 35 minutes in the oven.

Final Thoughts

This High-Protein Spinach and Artichoke Chicken Casserole is the perfect blend of nourishing and delicious, and it’s sure to become one of your go-to recipes. Remember to grease a baking dish with cooking spray or olive oil each time to get the best texture and easy cleanup. Whether you’re cooking for family, friends, or just yourself, this dish offers pure comfort with every bite. Go ahead, try it today—you won’t regret it!

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